2i2 only has ASIO drivers as far as I know (yes, its better if your system plays nice with it)
As for the monitor button; try it. I would think you would use it to avoid hearing the sound after being sent to the computer and back (latency).

Page 11 here (note the part about not routing the audio back out, which is tricky with the 2i2 as it does not come with mixer software for the computer, which adds to the confusion)
https://d3se566zfvnmhf.cloudfront.net/sites/default/files/focusrite/downloads/7317/scarlett-2i2-user-guide-v2.pdf

I think the Mono issue is related to whether you use balanced cables or not. If I recall.
The paragraph above (on page 10) explains the balanced cable system..

Couple related articles:
http://music.stackexchange.com/questions/31728/connecting-audio-interface-to-mixer

https://support.focusrite.com/hc/en-gb/articles/207547145-Can-I-use-Scarlett-MixControl-with-the-Scarlett-2i2-and-2i4-

Last edited by rharv; 06/12/16 01:23 AM.

I do not work here, but the benefits are still awesome
Make your sound your own!