Is this guitar track Audio or MIDI (have to ask).

Look in the Event Editor for any unexpected CC entries.

May want to check the setting for Prefs - MIDI - MIDI Out, and see if it is looking for the most recent controller and other Controller related options also.

What Audio drivers are you using?
ASIO or MME?
If MME then the playback CC changes can be delayed. If you adjust them for playback (to where they don't 'look right' but play back right, you can mess up the Render (which has no delay).

If using MME you may hear a delay from what you see to what you hear, but it will look right during playback.
When Rendering it will adjust be correct.
So (again if using MME) if you instead adjusted the Nodes to look wrong but play back right, they may be wrong at Render, as you adjusted for the delay which then disappears..

Hope that makes sense.
ASIO is a more accurate representation of the render.
Also, what version are you using?

I do not work here, but the benefits are still awesome
Make your sound your own!